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Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication
- Source :
- Current Biology-CB, Current Biology-CB, Elsevier, 2016, 26 (12), pp.1577-1584. ⟨10.1016/j.cub.2016.04.038⟩, Current biology : CB, vol 26, iss 12, idUS: Depósito de Investigación de la Universidad de Sevilla, Universidad de Sevilla (US), Corrochano, LM; Kuo, A; Marcet-Houben, M; Polaino, S; Salamov, A; Villalobos-Escobedo, JM; et al.(2016). Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. Current Biology, 26(12), 1577-1584. doi: 10.1016/j.cub.2016.04.038. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5jw144n1, Current Biology, 26(12), 1577. Cell Press, Current Biology-CB, 2016, 26 (12), pp.1577-1584. ⟨10.1016/j.cub.2016.04.038⟩, Academica-e: Repositorio Institucional de la Universidad Pública de Navarra, Universidad Pública de Navarra, idUS. Depósito de Investigación de la Universidad de Sevilla, instname, Current Biology, 26, 1577-1584. Cell Press, CURRENT BIOLOGY, Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Publication Year :
- 2015
-
Abstract
- Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3, 4, 5, 6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes. The work by the US Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The project was supported by European funds (European Regional Development Fund, ERDF), the Spanish Ministerio de Economía y Competitividad (BIO2005-25029-E, BIO2015-67148-R), and the Regional Government (Junta de Andalucía, P06-CVI-01650) to L.M.C.; Conacyt (Mexico) (FORDECYT-2012-02-193512) to A.H.-E.; the US National Science Foundation (MCB-0920581) to A.I.; and the Czech Science Foundation (13-33039S) to M.E.
- Subjects :
- 0301 basic medicine
Light
Transcription, Genetic
Mutant
Genome
Medical and Health Sciences
Phycomyces
Gene Duplication
Gene duplication
ComputingMilieux_MISCELLANEOUS
Genetics
Agricultural and Biological Sciences(all)
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
biology
Biological Sciences
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Fungal
Mucor
Multigene Family
Signal transduction
Genome, Fungal
General Agricultural and Biological Sciences
Transcription
Biotechnology
Signal Transduction
Evolution
1.1 Normal biological development and functioning
030106 microbiology
General Biochemistry, Genetics and Molecular Biology
Evolution, Molecular
03 medical and health sciences
Genetic
Underpinning research
Gene family
Gene
Biochemistry, Genetics and Molecular Biology(all)
Psychology and Cognitive Sciences
Fungi
Neurosciences
Molecular
biology.organism_classification
030104 developmental biology
Genome duplication
Perception
Phycomyces blakesleeanus
Generic health relevance
Developmental Biology
Subjects
Details
- ISSN :
- 18790445, 20052502, and 09609822
- Volume :
- 26
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Current biology : CB
- Accession number :
- edsair.doi.dedup.....df44494bfc2173eec8085a71417a9fa9