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Immunoadsorption in patients with autoimmune ion channel disorders of the peripheral nervous system
- Source :
- Atherosclerosis Supplements. 14:219-222
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Autoimmune ion channel disorders of the peripheral nervous system include myasthenia gravis, the Lambert–Eaton myasthenic syndrome, acquired neuromyotonia and autoimmune autonomic ganglionopathies. These disorders are characterized by the common feature of being mediated by IgG autoantibodies against identified target antigens, i.e. the acetylcholine receptor, the voltage-gated calcium and potassium channels, and the neuronal acetylcholine receptor. Moreover, experimental animal models have been identified for these diseases that respond to immunotherapy and are improved by plasmapheresis. On this basis, autoimmune ion channel disorders represent the ideal candidate for therapeutic apheresis. Immunoadsorption can be the treatment of choice when intensive apheretic protocols or long-term treatments must be performed, in patients needing frequent apheresis to keep a stable clinical condition, in case of unresponsiveness to corticosteroids and immunosuppressive treatments, or failure with TPE or intravenous immunoglobulins, and in patients with severe contraindications to long-term corticosteroids.
- Subjects :
- medicine.medical_treatment
Autoimmunity
Ion Channels
Autoimmune Diseases of the Nervous System
Myasthenia Gravis
Internal Medicine
medicine
Humans
Immunoadsorption
Immunosorbent Techniques
Autoantibodies
Acetylcholine receptor
business.industry
Autoantibody
Peripheral Nervous System Diseases
General Medicine
Immunotherapy
medicine.disease
Myasthenia gravis
Lambert-Eaton Myasthenic Syndrome
Treatment Outcome
Apheresis
medicine.anatomical_structure
Autonomic Nervous System Diseases
Immunoglobulin G
Peripheral nervous system
Immunology
Blood Component Removal
Plasmapheresis
Adsorption
Isaacs Syndrome
Immunosorbents
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 15675688
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis Supplements
- Accession number :
- edsair.doi.dedup.....df386a5f406c80035f4524fc004d3e7c