OK-432 Therapy for Lymphangiomas

Authors :: Ken Kimura
Richard J.H. Smith
Yutaka Sato
Diane K. Burke
Rolland I. Poust
Nancy M. Bauman
Source :: Archives of Otolaryngology - Head and Neck Surgery. 122:1195-1199
Publication Year :: 1996
Publisher :: American Medical Association (AMA), 1996.
Abstract: Objective: To assess the efficacy of OK-432 sclerotherapy in the treatment of lymphangiomas. Design: Nonrandomized trial; follow-up, 4 to 29 months. Setting: Academic tertiary referral medical center. Patients: Six children with presumed lymphangiomas; age range at initial treatment, 1 month to 7 years 10 months. Intervention: Fluoroscopically guided cyst aspiration, cystography, and injection of OK-432. Outcome Measures: Clinical and radiographic comparisons before and after therapy. Results: Complete response in 2 macrocystic lymphangiomas; no response in 3 microcystic lymphangiomas; and no response in 1 venous malformation. Conclusion: OK-432 sclerotherapy may be effective treatment for macrocystic lymphangiomas. Arch Otolaryngol Head Neck Surg. 1996;122:1195-1199