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Expression of proteins in intestinal middle villus epithelial cells of weanling piglets
- Source :
- Frontiers in Bioscience. 22:539-557
- Publication Year :
- 2017
- Publisher :
- IMR Press, 2017.
-
Abstract
- Weaning affects intestinal development in mammals, and pigs are often used as an animal model for analyzing the metabolism and physiology of differentiating middle villus intestinal epithelial cells (DIECs). To assess the impact of weaning on the proteomes of DIECs, we weaned piglets on day 14 and collected their jejunum on days 0, 1, 3, 5, and 7 after weaning. Levels of proteins associated with (a) Golgi vesicle transport and protein glycosylation; (b) monosaccharide, lipid, phospholipid, and nucleotide metabolism; and (c) Krebs cycle and respiratory electron transport chain were decreased in DIECs after weaning. These results indicate that weaning decreases nutrient metabolism in DIECs. Moreover, these results suggest that dietary interventions (e.g., supplementation with functional amino acids) are required to counter these changes.
- Subjects :
- 0301 basic medicine
040301 veterinary sciences
Sus scrofa
Phospholipid
Weanling
Weaning
Biology
Respiratory electron transport chain
0403 veterinary science
Jejunum
Andrology
03 medical and health sciences
chemistry.chemical_compound
medicine
Animals
Intestinal Mucosa
Peptide Chain Initiation, Translational
chemistry.chemical_classification
Proteins
Epithelial Cells
04 agricultural and veterinary sciences
Metabolism
Lipid Metabolism
Amino acid
Citric acid cycle
Protein Transport
030104 developmental biology
medicine.anatomical_structure
chemistry
Animal Nutritional Physiological Phenomena
Energy Metabolism
Subjects
Details
- ISSN :
- 10934715 and 10939946
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Frontiers in Bioscience
- Accession number :
- edsair.doi.dedup.....df2149bc48c5bdf50d7e59d9f214d91d