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Neonatal Rhizomelic Chondrodysplasia Punctata Type 1: Weaving Evidence Into Clinical Practice
- Source :
- The Journal of perinatalneonatal nursing. 31(4)
- Publication Year :
- 2017
-
Abstract
- Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic peroxisome biogenesis disorder with a reported incidence of 1 in 100 000 live births. The 3 genetic subtypes of RCDP are acquired by an autosomal recessive inheritance pattern. RCDP type 1 accounts for greater than 90% of all aggregate cases. Differentiating between the 3 subtypes of RCDP, as well as disorders characterized by similar punctate cartilaginous changes, is essential to guide an appropriate postnatal plan of care. Management strategies are focused toward associated clinical manifestations and require an interdisciplinary approach including ophthalmology, cardiovascular, endocrine, physical and occupational therapy, and neurology. Purposeful and frequent collaboration among all members of the neonatal/pediatric interdisciplinary team is necessary to optimize outcomes for the neonate and the family unit. The purpose of this article is to anticipate the needs of both patients with known and prenatal diagnosis of RCDP type 1 and patients with suspected clinical diagnosis of RCDP type 1 in the immediate neonatal period and to guide the appropriate plan of care. This article presents a case report of type I RCDP, as well as describes genetic influences, symptoms, diagnosis, management, and prognosis.
- Subjects :
- Occupational therapy
Adult
Male
medicine.medical_specialty
Pediatrics
Neurology
Prenatal diagnosis
Critical Care Nursing
03 medical and health sciences
0302 clinical medicine
Pregnancy
Prenatal Diagnosis
Maternity and Midwifery
medicine
Humans
Chondrodysplasia punctata
Genetic Predisposition to Disease
Peroxisomal Targeting Signal 2 Receptor
030219 obstetrics & reproductive medicine
Rhizomelic chondrodysplasia punctata
Chondrodysplasia Punctata, Rhizomelic
business.industry
Cesarean Section
Incidence (epidemiology)
Infant, Newborn
medicine.disease
Prognosis
Combined Modality Therapy
Clinical Practice
Apgar Score
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15505073
- Volume :
- 31
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of perinatalneonatal nursing
- Accession number :
- edsair.doi.dedup.....df1bf85c6abe5a01414d144561b6e9b6