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Cumulative small effect genetic markers and the detection of advanced colorectal neoplasias by population screening
- Source :
- Hereditary Cancer in Clinical Practice, Vol 10, Iss Suppl 4, p A26 (2012), Hereditary Cancer in Clinical Practice
- Publisher :
- Springer Nature
-
Abstract
- With the instigation of population screening strategies to reduce the burden of colorectal cancer, a cost effective approach remains an elusive goal. Genetic markers associated with colorectal cancer have the potential to be used for the early identification of patient groups at elevated risk of disease. The choice of genetic markers that can be used for screening purposes is population specific. In this report we have genotyped 3059 individuals for 13 markers that have been associated with colorectal cancer risk. The participants underwent colonoscopy and controls with clear colonoscopy (1838) were compared to cases with advanced colorectal neoplasia (213). Logistic regression analysis, adjusted for sex and age at colonoscopy, showed that only one of the markers (rs4779584) was significantly associated with the risk of advanced colorectal neoplasia (OR = 1.93; 95% CI = 1.22 – 2.99; p-value = 0.004; sensitivity = 20%). A combination of 7 markers (rs4779584, rs2578187, rs3802842, rs6983267, NOD2 5020insC, rs4464148 and rs4939827) showed an optimal trade-off minimizing the number of markers considered, while maximizing the relative size of the carrier group and the risk associated to it (e.g. for at least 4 cumulated risk markers, OR = 4.23; 95% CI = 1.5 – 10.4; p-value = 0.0036; sensitivity = 4.7%). For this combination of 7 markers the linear cumulative risk model was statistically significant (p=7.0·10-5) after adjustment for sex and age at colonoscopy. The identification of such cumulative models could be valuable in better defining a group of persons, within a given population, that are most likely to benefit from screening for colorectal cancer.
- Subjects :
- Oncology
medicine.medical_specialty
lcsh:QH426-470
Colorectal cancer
Population
Colonoscopy
Disease
Bioinformatics
Logistic regression
lcsh:RC254-282
Internal medicine
medicine
education
Genetics (clinical)
education.field_of_study
medicine.diagnostic_test
business.industry
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Human genetics
lcsh:Genetics
Genetic marker
Meeting Abstract
Population screening
business
Subjects
Details
- Language :
- English
- ISSN :
- 18974287
- Volume :
- 10
- Issue :
- Suppl 4
- Database :
- OpenAIRE
- Journal :
- Hereditary Cancer in Clinical Practice
- Accession number :
- edsair.doi.dedup.....df1a4ea35266a2d4b198cd89cf2c9fa2
- Full Text :
- https://doi.org/10.1186/1897-4287-10-s4-a26