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Impact of childhood adversities on depression in early adulthood: A longitudinal cohort study of 478,141 individuals in Sweden
- Source :
- Journal of Affective Disorders. 223:95-100
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objective Although the relationship between childhood adversity (CA) and depression is widely accepted, there is little information on what proportion of depression is attributable to CA. Method We used a Swedish cohort of 478,141 individuals born in 1984–1988 in Sweden. Register-based CA indicators included parental death, parental substance abuse and psychiatric morbidity, parental criminality, parental separation, public assistance recipiency, child welfare intervention, and residential instability. Estimates of risk of depression, measured as retrieval of prescribed antidepressants and/or psychiatric care with a clinical diagnosis of depression, between 2006 and 2012 were calculated as Hazard Ratios (HR) with 95% confidence intervals (CI), using a Cox regression analysis. Results All CAs predicted depression in early adulthood. Furthermore, the predictive association between the CA indicators and depression was graded, with highest HRs observed for 4+ CAs (HR: 3.05 (95% CI 2.83–3.29)) for a clinical diagnosis for depression and HR: 1.32 (95% CI 1.25–1.41) for antidepressant medication after adjustments were made for important confounding factors. Of the studied CAs, child welfare intervention entailed highest HR for depression. Conclusion Regardless of causality issues, children and youth with a history of multiple CA should be regarded as a high-risk group for depression by professionals in social, and health services that come into contact with this group.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Parental Death
Cohort Studies
Life Change Events
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Epidemiology
medicine
Humans
Longitudinal Studies
Child
Psychiatry
Depression (differential diagnoses)
Sweden
Depressive Disorder
Proportional hazards model
Hazard ratio
medicine.disease
030227 psychiatry
Substance abuse
Psychiatry and Mental health
Clinical Psychology
Adult Survivors of Child Adverse Events
Cohort
Female
Psychology
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....df0ff8280500a6947d6b1c2a8c394150