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Biological Active Ingredients of Traditional Chinese Herb Astragalus membranaceus on Treatment of Diabetes: A Systematic Review
- Source :
- Scopus-Elsevier, ResearcherID
- Publication Year :
- 2015
- Publisher :
- Bentham Science Publishers Ltd., 2015.
-
Abstract
- Diabetes mellitus (DM) is a serious chronic metabolic disease which disease afflicting at present now afflicts approximately 4% of world population worldwide. Nowadays, the need for more potent and safe drugs to supply the present anti-diabetic and treated drugs has become an imperative. Astragalus membranaceus, the most common Chinese herb and key-component of many Chinese herbal anti-diabetic formulas, is rich in anti-diabetic compounds: polysaccharides (APS), saponins (ASS), and flavonoids (ASF) etc. Because of its various biological activities, especially its antidiabetic properties, that continuously arouse different studies. Recent studies focused on type 1 and type 2 treatment, respectively caused by autoimmune destruction of pancreatic beta cells and insulin resistance and deficient glucose metabolism. Its total polysaccharides, saponins and flavonoids fractions and several isolated compounds have been the most studied. This paper discusses diabetic treatment and pharmacological action of the biological ingredients in relation to diabetes mellitus and diabetic complications.
- Subjects :
- food.ingredient
astragalus flavonoids
Disease
Pharmacology
food
Insulin resistance
Polysaccharides
Pancreatic beta Cells
Diabetes mellitus
Drug Discovery
Animals
Humans
Medicine
astragaloside
astragalus membranaceus, diabetes mellitus, astragalus polysaccharides, astragalus saponins, astragalus flavonoids, astragaloside
Flavonoids
Active ingredient
biology
Traditional medicine
business.industry
General Medicine
Astragalus propinquus
Saponins
biology.organism_classification
medicine.disease
astragalus membranaceus
Pharmacological action
Astragalus
astragalus polysaccharides
Herb
diabetes mellitus
astragalus saponins
business
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 13895575
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Mini-Reviews in Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....df0cbbbf926d67f28d773034050556f5