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Current and Future Trends in Magnetic Resonance Imaging Assessments of the Response of Breast Tumors to Neoadjuvant Chemotherapy
- Source :
- Journal of Oncology, Vol 2010 (2010), Journal of Oncology
- Publication Year :
- 2010
- Publisher :
- Hindawi Limited, 2010.
-
Abstract
- The current state-of-the-art assessment of treatment response in breast cancer is based on the response evaluation criteria in solid tumors (RECIST). RECIST reports on changes in gross morphology and divides response into one of four categories. In this paper we highlight how dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) may be able to offer earlier, and more precise, information on treatment response in the neoadjuvant setting than RECIST. We then describe how longitudinal registration of breast images and the incorporation of intelligent bioinformatics approaches with imaging data have the potential to increase the sensitivity of assessing treatment response. We conclude with a discussion of the potential benefits of breast MRI at the higher field strength of 3T. For each of these areas, we provide a review, illustrative examples from clinical trials, and offer insights into future research directions.
- Subjects :
- medicine.medical_specialty
Pathology
Treatment response
medicine.medical_treatment
Review Article
lcsh:RC254-282
Imaging data
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Breast cancer
medicine
Breast MRI
skin and connective tissue diseases
Chemotherapy
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
3. Good health
Clinical trial
Oncology
Response Evaluation Criteria in Solid Tumors
030220 oncology & carcinogenesis
Radiology
business
Subjects
Details
- ISSN :
- 16878469 and 16878450
- Volume :
- 2010
- Database :
- OpenAIRE
- Journal :
- Journal of Oncology
- Accession number :
- edsair.doi.dedup.....df0225d941f02cb1b19a4aa6dfdd89f5