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An Update on the Role of Adipose Tissues in Psoriasis
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 10 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
obesity
Mini Review
Immunology
Adipokine
Adipose tissue
adipocyte
leptin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Downregulation and upregulation
Adipokines
Adipocyte
Psoriasis
Adipocytes
Immunology and Allergy
Medicine
Animals
Humans
Skin
business.industry
adipose tissue—obesity
Leptin
Fatty Acids
psoriasis
medicine.disease
adipokine cytokines
030104 developmental biology
chemistry
Adipose Tissue
macrophage—cell
Resistin
business
lcsh:RC581-607
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....def671013add42ffe80b94c8864a246b