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DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population
- Source :
- Appetite. 120
- Publication Year :
- 2017
-
Abstract
- Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p < 0.0001) were used to select those CpGs that showed best correlation with BMI. A total of 29 CpGs at taste transducing genes met the FDR criteria. However, only 12 CpGs remained statistically significant after linear regression analyses adjusted for age and sex. These included cg15743657 (TAS1R2), cg02743674 (TRPM5), cg01790523 (SCN9A), cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C). Interestingly, most of them were implicated in the sweet taste signaling pathway, except CACNA1C (sour taste). In addition, TAS1R2 methylation at cg15743657 was strongly correlated with total energy (p < 0.0001) and carbohydrate intakes (p < 0.0001). This study suggests that methylation in genes related to sweet taste could be an epigenetic mechanism associated with obesity.
- Subjects :
- 0301 basic medicine
Adult
Male
Taste
medicine.medical_specialty
Microarray
Biology
Body Mass Index
Receptors, G-Protein-Coupled
03 medical and health sciences
Eating
TAS1R2
Internal medicine
medicine
Dietary Carbohydrates
Humans
TRPM5
General Psychology
Nutrition and Dietetics
Taste Transduction Pathway
Taste Perception
Methylation
DNA Methylation
Middle Aged
030104 developmental biology
Endocrinology
DNA methylation
Linear Models
CALHM1
Female
Signal Transduction
Subjects
Details
- ISSN :
- 10958304
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Appetite
- Accession number :
- edsair.doi.dedup.....deee199c29e08e78df74887eea9613bf