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Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2)
- Source :
- Anti-Cancer Drugs, Anti-Cancer Drugs, Lippincott, Williams & Wilkins, 2006, 17, pp.239-244, HAL, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2006
- Publisher :
- Lippincott Williams & Wilkins, 2006.
-
Abstract
- Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP-binding cassette (ABC) transporter superfamily. It is able to efflux a broad range of anti-cancer drugs through the cellular membrane, thus limiting their anti-proliferative effects. Due to its relatively recent discovery in 1998, and in contrast to the other ABC transporters P-glycoprotein (MDR1/ABCB1) and multidrug resistance-associated protein (MRP1/ABCC1), only a few BCRP inhibitors have been reported. This review summarizes the known classes of inhibitors that are either specific for BCRP or also inhibit the other multidrug resistance ABC transporters. Information is presented on structure-activity relationship aspects and how modulators may interact with BCRP. © 2006 Lippincott Williams & Wilkins.
- Subjects :
- Cancer Research
Indoles
Abcg2
Receptors, Cytoplasmic and Nuclear
ATP-binding cassette transporter
Pharmacology
03 medical and health sciences
Structure-Activity Relationship
0302 clinical medicine
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Structure–activity relationship
ATP Binding Cassette Transporter, Subfamily G, Member 2
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Pharmacology (medical)
030304 developmental biology
Flavonoids
0303 health sciences
biology
Transporter
Drug Resistance, Multiple
3. Good health
Neoplasm Proteins
Multiple drug resistance
Oncology
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
Cancer cell
ABCC1
biology.protein
ATP-Binding Cassette Transporters
Efflux
Subjects
Details
- Language :
- English
- ISSN :
- 09594973 and 14735741
- Database :
- OpenAIRE
- Journal :
- Anti-Cancer Drugs, Anti-Cancer Drugs, Lippincott, Williams & Wilkins, 2006, 17, pp.239-244, HAL, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....deebf251a32f1011a02e52ed57550b6c