Factor VIII-Intron 1 Inversion of Hemophilia A Patients In West Anatolia

Authors :: Seckin Cagirgan
Murat Tombuloglu
Kaan Kavakli
Sacide Pehlivan
Mehmet Yilmaz
Omay Bedii
Mustafa Pehlivan
Filiz Büyükkeçeci
Ege Üniversitesi
Source :: Balkan Journal of Medical Genetics, Vol 10, Iss 1, Pp 49-50 (2007)
Publication Year :: 2007
Publisher :: Walter de Gruyter GmbH, 2007.
Abstract: WOS: 000259504600009<br />Hemophilia A (HA) is a hereditary, life-threatening and disabling disorder. In this study, we have examined 61 unrelated HA patients in order to identify the incidence of the intron 1 factor VIII (FVIII) gene inversion in the West Anatolian population. According to the results of DNA analyses of the 61 HA patients, no intron 1 inversion of the FVIII gene was found.<br />Ege University Research Fund (EBIL TEM)Ege University<br />We are grateful to Dr. Cemal Un (Bogazici University, Istanbul, Turkey) for the mutant DNA sample. This study was supported by Ege University Research Fund (EBIL TEM).