Back to Search
Start Over
von Willebrand Disease and other hereditary haemostatic factor deficiencies in women with a history of postpartum haemorrhage
- Source :
- Haemophilia. 26:97-105
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Introduction Postpartum haemorrhage (PPH) is the main cause of maternal morbidity and mortality globally, but it is far more important in non-developed countries. PPH represents 25% of all maternal deaths worldwide. Women with von Willebrand disease (VWD) and other inherited haemorrhagic disorders are at increased risk of PPH. Our aim was to establish a probable association of severe PPH in women with a history of haemostatic abnormalities. Methods An observational, controlled study of adult women with a one or more episodes of severe PPH requiring treatment in an intensive care unit or >10 units of blood products during the 24-hour period after diagnosis and their controls. The tests performed were blood cell count, blood group, renal, viral, liver function and haemostatic tests, fibrinogen, activity of the plasma factors and specific test to diagnose and classify VWD. Results We included 124 women with 133 PPH events and their controls. The median age at the first event was 25.5 years old. Results were significantly different between the groups in terms of fibrinogen concentration, VWF:Ag, VWF:RCo and FVIII. A specific diagnosis was established in 69 (55.6) and 4 (3.2%) patients in the PPH group and controls, respectively. Of 61 patients with VWD, 57 had type 1, two had type 2A, and another two had type 2B. Conclusion Our results show a relationship between PPH and inherited haemostatic disorders. VWD was the most frequent diagnosis. Appropriate and opportune diagnosis before pregnancy of inherited haemostatic disorders may be important to effectively prevent and treat PPH.
- Subjects :
- Adult
medicine.medical_specialty
Coagulation Protein Disorders
030204 cardiovascular system & hematology
Fibrinogen
Hemostatics
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Von Willebrand factor
Pregnancy
law
medicine
Von Willebrand disease
Humans
Genetics (clinical)
biology
business.industry
Obstetrics
Postpartum Hemorrhage
Hematology
General Medicine
medicine.disease
Postpartum haemorrhage
Intensive care unit
von Willebrand Diseases
Increased risk
biology.protein
Female
Liver function
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 13652516 and 13518216
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Haemophilia
- Accession number :
- edsair.doi.dedup.....ded5ee7b36d9cc726431022e2fee8c03