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Effect of phosphate amendment on relative bioavailability and bioaccessibility of lead and arsenic in contaminated soils
- Source :
- Journal of hazardous materials. 339
- Publication Year :
- 2017
-
Abstract
- Hand-to-mouth activity is an important pathway for children's exposure to contaminated soils, which is often co-contaminated by Pb and As in mining and smelting sites. To reduce soil Pb risk to humans by oral exposure, phosphate amendments have been used to reduce Pb relative bioavailability (RBA), but its efficiency has not been investigated using validated in vitro assays nor its influence on As-RBA. Here, 5 contaminated soils (A-E) were amended with 0.5% phosphoric acid (PA) to study its effect on Pb- and As- RBA using a newly-developed mouse kidney model and bioaccessibility using 4 in vitro assays including UBM, SBRC, IVG, and PBET. Based on the mouse kidney model, Pb-RBA in PA-amended soils decreased from 14.2-62.5% to 10.1-29.8%. In contrast, As-RBA decreased from 26.5% to 15.9% in soil B but increased from 27.5 to 41.2% in soil D, with changes being insignificant in 3 other soils (35.8-58.8 to 28.1-61.1%). When assessing Pb bioaccessibility in PA-amended soils, decreased bioaccessibility were found using PBET and SBRC. For As, its bioaccessibility increased in PA-amended soils, inconsistent with in vivo data. Our results shed light on the importance of method selection to assess risk in Pb- and As-contaminated soils amended with phosphate.
- Subjects :
- Environmental Engineering
Health, Toxicology and Mutagenesis
0211 other engineering and technologies
Amendment
chemistry.chemical_element
Biological Availability
02 engineering and technology
010501 environmental sciences
Kidney
complex mixtures
01 natural sciences
Arsenic
Phosphates
chemistry.chemical_compound
Environmental Chemistry
Animals
Soil Pollutants
Waste Management and Disposal
Phosphoric acid
0105 earth and related environmental sciences
021110 strategic, defence & security studies
Mice, Inbred BALB C
Phosphate
Pollution
Soil contamination
Bioavailability
chemistry
Lead
Environmental chemistry
Soil water
Female
Subjects
Details
- ISSN :
- 18733336
- Volume :
- 339
- Database :
- OpenAIRE
- Journal :
- Journal of hazardous materials
- Accession number :
- edsair.doi.dedup.....decfcfa6a813677f77c5c8228620c7a2