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Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy
- Source :
- International Journal of Environmental Research and Public Health, Volume 18, Issue 11, International Journal of Environmental Research and Public Health, Vol 18, Iss 5709, p 5709 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.
- Subjects :
- medicine.medical_specialty
Amniotic fluid
placenta
Health, Toxicology and Mutagenesis
first trimester pregnancy
Article
03 medical and health sciences
0302 clinical medicine
Pregnancy
Placenta
Humans
Medicine
030212 general & internal medicine
Pregnancy Complications, Infectious
Retrospective Studies
Fetus
biology
SARS-CoV-2
business.industry
Obstetrics
Pregnancy Outcome
Public Health, Environmental and Occupational Health
Infant
COVID-19
neutralizing antibody
Gestational age
medicine.disease
Infectious Disease Transmission, Vertical
vertical infection transmission
Reverse transcription polymerase chain reaction
COVID-19 antibody
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cord blood
biology.protein
Female
pathology
Antibody
business
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....dec5a859a9d9d4b0422655cb5ecdfdfe