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Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis.
- Subjects :
- Aging
Pathology
genetic structures
Blood Pressure
Pilot Projects
030204 cardiovascular system & hematology
01 natural sciences
Translational Research, Biomedical
0302 clinical medicine
Medicine
Skin
Aged, 80 and over
Multidisciplinary
Angiography
Pathophysiology
Forearm
Hypertension
Disease Progression
Female
Medical imaging
Perfusion
Tomography, Optical Coherence
Adult
medicine.medical_specialty
Adolescent
Science
Hyperemia
Article
Microcirculation
010309 optics
Vascular health
Young Adult
03 medical and health sciences
0103 physical sciences
Humans
Reactive hyperemia
Aged
business.industry
Optical coherence tomography angiography
Translational research
Skin manifestations
Cardiovascular biology
eye diseases
Blood pressure
Microvessels
Histopathology
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....dec5a6f0808c435aae5a07cb79328b29