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Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance
- Source :
- Pediatric Endocrinology Diabetes and Metabolism. 28:101-103
- Publication Year :
- 2022
- Publisher :
- Termedia Sp. z.o.o., 2022.
-
Abstract
- Many C-peptide assays are commercially available for research and routine use. However, not all assays yield consistent results, especially in the low concentration ranges. We searched the literature describing C-peptide measurements to assess which assays are mainly used in the diabetes research field and if they are specified. Percentages of publications on C-peptide measurements in type 1 diabetes (T1D), type 2 diabetes (T2D) and other forms of diabetes were 32%, 54% and 14%, respectively. In only 54% of the publications the used assay was specified. Information on detection limit, measurement range and variation was provided in 12%, 2% and 11% of publications, respectively. In 22% of all publications no C-peptides concentrations were mentioned. This may be a problem especially for T1D research, where measuring very low levels of C-peptide is becoming increasingly important and concordance between assays is low.
Details
- ISSN :
- 2081237X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Pediatric Endocrinology Diabetes and Metabolism
- Accession number :
- edsair.doi.dedup.....dec10a0ffbd01344c90bb569805ad371