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How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease?
- Source :
- Digestive Diseases and Sciences. 40:1317-1324
- Publication Year :
- 1995
- Publisher :
- Springer Science and Business Media LLC, 1995.
-
Abstract
- Twenty-four normal subjects and 64 symptomatic patients with various degrees of reflux disease (24 with reflux symptoms without esophagitis and 21 with mild and 19 with severe esophagitis) underwent quantitative 24-hr intraesophageal pH monitoring. Various reflux parameters during supine, interprandial, and postprandial periods were examined by binary logistic regression and by CART analysis to determine the sensitivity and specificity to separate the various groups of subjects and patients. The distinction was excellent between asymptomatic controls and patients with severe erosive esophagitis (sensitivity and specificity both 100% by logistic regression and 95% and 88%, respectively, by CART), but discrimination was poor when asymptomatic controls were compared to symptomatic patients without esophagitis (71% and 79% by logistic regression and 75% and 92% by CART), which is the most important indication for pH recording in clinical practice. A 3-hr postprandial pH recording was inadequate to distinguish the various groups. The acidity of the reflux episodes during the night appeared to be a crucial factor in the development of severe erosive esophagitis. The duration of esophageal acid exposure was another important factor in the development of reflux lesions.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Physiology
Logistic regression
Sensitivity and Specificity
Asymptomatic
Gastroenterology
Esophagus
Internal medicine
medicine
Humans
Reflux esophagitis
Aged
Monitoring, Physiologic
Aged, 80 and over
Esophageal disease
business.industry
Reflux
Hydrogen-Ion Concentration
Middle Aged
medicine.disease
Circadian Rhythm
Logistic Models
Postprandial
medicine.anatomical_structure
Multivariate Analysis
Gastroesophageal Reflux
Female
Esophagoscopy
medicine.symptom
business
Esophagitis
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....deb8c4b5af437597bef435b681950e6d