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Progesterone receptor expression is associated with longer overall survival within high-grade histotypes of endometrial carcinoma: A Canadian high risk endometrial cancer consortium (CHREC) study
Progesterone receptor expression is associated with longer overall survival within high-grade histotypes of endometrial carcinoma: A Canadian high risk endometrial cancer consortium (CHREC) study
- Source :
- Gynecologic Oncology. 141:559-563
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Objective To assess the association of hormone receptor expression with outcome in high-grade endometrial carcinomas. Methods This study included three sites participating in the Canadian High Risk Endometrial Cancer (CHREC) consortium. Sections from tissue microarrays containing cases with a diagnosis of endometrioid grade 3 (EC3) and endometrial serous carcinoma (ESC) were assessed for estrogen (ER) and progesterone receptor (PR) expression by immunohistochemistry. Expression was considered present if >1% of tumor cell nuclei were labeled. Associations with overall survival were assessed. Results ER expression was present in 168/216 (78%) of EC3 and 124/192 (65%) of ESC. PR expression was present in 148/212 (70%) of EC3 and 83/196 (42%) of ESC. PR expression was significantly associated with favorable overall survival in EC3 and ESC (log rank, p =0.018 and p =0.0024) but ER expression was not. PR expression was significantly associated with favorable overall survival in EC3 independent of age, stage, center and lymph-vascular invasion (hazard ratio=0.457, 95% CI 0.257–0.811, p =0.0075) as well as in stage I and II ESC (hazard ratio=0.266, 95% CI 0.094–0.750, p =0.0123). Conclusion Our data provide support for the assessment of the PR expression status in EC3 and ESC. Future work will be required to determine how PR expression may be incorporated into management of patients with EC3 and ESC.
- Subjects :
- 0301 basic medicine
Oncology
Canada
medicine.medical_specialty
Serous carcinoma
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Progesterone receptor
medicine
Carcinoma
Humans
Survival rate
Neoplasm Staging
Gynecology
Tissue microarray
business.industry
Endometrial cancer
Hazard ratio
Obstetrics and Gynecology
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Endometrial Neoplasms
Survival Rate
Serous fluid
030104 developmental biology
Receptors, Estrogen
Tissue Array Analysis
030220 oncology & carcinogenesis
Female
Neoplasm Grading
Receptors, Progesterone
business
Carcinoma, Endometrioid
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 141
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....deafb9948ab75ae0c608725529426879
- Full Text :
- https://doi.org/10.1016/j.ygyno.2016.04.008