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The Preventive Effect of IL-1beta Antagonist on Diabetic Peripheral Neuropathy
- Source :
- Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:753-759
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Objective: To investigate the relationship between Interleukin-1beta (IL-1beta) and diabetic peripheral neuropathy (DPN) using animal models. Materials: The rat model of diabetic neuropathy was induced by intraperitoneal injection of a single dose of streptozotocin (STZ) at 65mg/kg. Diabetic rats were randomly divided into two groups (10 each), one treated with 0.9% saline (DMS group) and the other with interleukin-1 receptor antagonist (IL-1RA) at 50mg/kg (DMI group) twice a day for 5 weeks. Ten normal rats matched for weight, age and sex served as normal controls (Con group) and were treated with saline. Morphologic studies of sciatic nerves were achieved using light and transmission electron microscopy. Results: Transmission electron microscopy of the sciatic nerve showed the ultrastructure of myelin and the axon in the IL-1RA group was highly protected compared to diabetic controls. Conclusions: High levels of circulating IL-1beta may be associated with the risk of DPN and anti-IL-1 treatment may provide a potential strategy for the prevention of diabetic neuropathy.
- Subjects :
- Male
medicine.medical_specialty
Diabetic neuropathy
medicine.drug_class
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Interleukin-1beta
Intraperitoneal injection
030209 endocrinology & metabolism
Diabetes Mellitus, Experimental
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Diabetic Neuropathies
Internal medicine
medicine
Animals
Immunology and Allergy
Saline
business.industry
Antagonist
medicine.disease
Receptor antagonist
Streptozotocin
Recombinant Proteins
Rats
Interleukin 1 Receptor Antagonist Protein
Treatment Outcome
Peripheral neuropathy
Endocrinology
Sciatic nerve
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 18715303
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Endocrine, Metabolic & Immune Disorders - Drug Targets
- Accession number :
- edsair.doi.dedup.....deaa6beed9deff974cf87875eaf50a9b