Back to Search
Start Over
NEU3 Sialidase Strictly Modulates GM3 Levels in Skeletal Myoblasts C2C12 Thus Favoring Their Differentiation and Protecting Them from Apoptosis
- Source :
- Europe PubMed Central
- Publication Year :
- 2008
-
Abstract
- Membrane-bound sialidase NEU3, often referred to as the "ganglioside sialidase", has a critical regulatory function on the sialoglycosphingolipid pattern of the cell membrane, with an anti-apoptotic function, especially in cancer cells. Although other sialidases have been shown to be involved in skeletal muscle differentiation, the role of NEU3 had yet to be disclosed. Herein we report that NEU3 plays a key role in skeletal muscle differentiation by strictly modulating the ganglioside content of adjacent cells, with special regards to GM3. Induced down-regulation of NEU3 in murine myoblasts C2C12, even when partial, totally inhibits their capability to differentiate by increasing GM3 level above a critical point, that causes EGFR inhibition (and ultimately its down-regulation), and an higher responsiveness of myoblasts to the apoptotic stimuli. ispartof: Journal of Biological Chemistry vol:283 issue:52 pages:36265-36271 ispartof: location:United States status: published
- Subjects :
- Down-Regulation
Neuraminidase
Glycobiology and Extracellular Matrices
Biology
Sialidase
Biochemistry
Cell Line
Cell membrane
Mice
SKELETAL MYOBLASTS
DIFFERENTIATION
APOPTOSIS
medicine
Animals
G(M3) Ganglioside
Myocyte
Gene Silencing
Epidermal growth factor receptor
skeletal muscle
Muscle, Skeletal
Molecular Biology
ganglioside GM3
Sphingolipids
Ganglioside
Epidermal Growth Factor
Hydrolysis
Skeletal muscle
C2V12
Cell Biology
sialidase NEU3
cell differentiation
Cell biology
ErbB Receptors
medicine.anatomical_structure
Models, Chemical
Cancer cell
biology.protein
C2C12
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....dea94eab059fb14a39829ebd659dc4b0