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In-vivo monitoring of acute DSS-Colitis using Colonoscopy, high resolution Ultrasound and bench-top Magnetic Resonance Imaging in Mice
- Source :
- European radiology. 25(10)
- Publication Year :
- 2014
-
Abstract
- The aim of this study was to establish and evaluate (colour Doppler-) high-resolution-ultrasound (hrUS) and bench-top magnetic resonance imaging (btMRI) as new methods to monitor experimental colitis. hrUS, btMRI and endoscopy were performed in mice without colitis (n = 15), in mice with acute colitis (n = 14) and in mice with acute colitis and simultaneous treatment with infliximab (n = 19). Determination of colon wall thickness using hrUS (32 MHz) and measurement of the cross-sectional colonic areas by btMRI allowed discrimination between the treatment groups (mean a vs. b vs. c – btMRI: 922 vs. 2051 vs. 1472 pixel, hrUS: 0.26 vs. 0.45 vs. 0.31 mm). btMRI, endoscopy, hrUS and colour Doppler-hrUS correlated to histological scoring (p
- Subjects :
- Male
medicine.medical_specialty
Colon
Colonoscopy
Multimodal Imaging
Diagnosis, Differential
Gastrointestinal Agents
In vivo
medicine
Animals
Radiology, Nuclear Medicine and imaging
Colitis
Ultrasonography, Doppler, Color
Acute colitis
Neuroradiology
Mice, Inbred BALB C
medicine.diagnostic_test
business.industry
Ultrasound
Dextran Sulfate
Magnetic resonance imaging
General Medicine
medicine.disease
Magnetic Resonance Imaging
Infliximab
Endoscopy
Cross-Sectional Studies
Acute Disease
Irritants
Feasibility Studies
Radiology
business
Subjects
Details
- ISSN :
- 14321084
- Volume :
- 25
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....dea364a29530512721808307182b36bd