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Profile of Hepatobiliary Dysfunction in Hematopoietic Stem Cell Transplant Recipients – An Indian Perspective
- Source :
- J Clin Exp Hepatol
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- BACKGROUND/AIMS: Hematopoietic stem cell transplantation (HSCT) is an established curative modality for various hematological malignancies and other diseases. Hepatobiliary dysfunction and subsequent sequelae constitute a common cause of morbidity and mortality in post-transplant scenario. However, data among Indian HSCT recipients is lacking. METHODS: One hundred and one HSCT recipients (37 prospective and 64 retrospective) were followed up for hepatobiliary dysfunction in the post-transplant period. The causes for hepatobiliary dysfunction were categorized as sinusoidal obstruction syndrome (SOS), formerly known as veno-occlusive disease (VOD); acute and chronic graft-versus- host disease (GVHD); drug-induced liver injury (DILI); viral infections and miscellaneous causes including bacterial, fungal and unknown causes based on clinical and laboratory evidence. RESULTS: Among the 101 transplants, 56.44% (n = 57) were allogenic transplants, and 43.56% (n = 44) were autologous transplants. Hepatobiliary dysfunction was observed among 71 (70.30%) patients in first 30 days and overall, among 78 (77.23%) patients. Incidence of hepatobiliary dysfunction was higher among allogenic transplant patients compared to autologous transplants (91.23% vs. 59.09%, p
- Subjects :
- Liver injury
medicine.medical_specialty
Hepatology
business.industry
medicine.medical_treatment
Incidence (epidemiology)
Indian population
Hematopoietic stem cell
Hematopoietic stem cell transplantation
Disease
medicine.disease
03 medical and health sciences
surgical procedures, operative
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Internal medicine
medicine
Original Article
030211 gastroenterology & hepatology
Transplant patient
business
Host disease
Subjects
Details
- ISSN :
- 09736883
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical and Experimental Hepatology
- Accession number :
- edsair.doi.dedup.....de8ca8e08f3a29661c45419bf416426c