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Curcumin Nanomedicine: A Road to Cancer Therapeutics
- Source :
- Current Pharmaceutical Design. 19:1994-2010
- Publication Year :
- 2013
- Publisher :
- Bentham Science Publishers Ltd., 2013.
-
Abstract
- Cancer is the second leading cause of death in the United States. Conventional therapies cause widespread systemic toxicity and lead to serious side effects which prohibit their long term use. Additionally, in many circumstances tumor resistance and recurrence is commonly observed. Therefore, there is an urgent need to identify suitable anticancer therapies that are highly precise with minimal side effects. Curcumin is a natural polyphenol molecule derived from the Curcuma longa plant which exhibits anticancer, chemo-preventive, chemo- and radio-sensitization properties. Curcumin’s widespread availability, safety, low cost and multiple cancer fighting functions justify its development as a drug for cancer treatment. However, various basic and clinical studies elucidate curcumin’s limited efficacy due to its low solubility, high rate of metabolism, poor bioavailability and pharmacokinetics. A growing list of nanomedicine(s) using first line therapeutic drugs have been approved or are under consideration by the Food and Drug Administration (FDA) to improve human health. These nanotechnology strategies may help to overcome challenges and ease the translation of curcumin from bench to clinical application. Prominent research is reviewed which shows that advanced drug delivery of curcumin (curcumin nanoformulations or curcumin nanomedicine) is able to leverage therapeutic benefits by improving bioavailability and pharmacokinetics which in turn improves binding, internalization and targeting of tumor(s). Outcomes using these novel drug delivery systems have been discussed in detail. This review also describes the tumor-specific drug delivery system(s) that can be highly effective in destroying tumors. Such new approaches are expected to lead to clinical trials and to improve cancer therapeutics.
- Subjects :
- Drug
Curcumin
Chemistry, Pharmaceutical
media_common.quotation_subject
Biological Availability
Pharmacology
Article
chemistry.chemical_compound
Pharmacokinetics
Neoplasms
Drug Discovery
Animals
Humans
Technology, Pharmaceutical
Medicine
media_common
Drug Carriers
business.industry
Cancer
medicine.disease
Antineoplastic Agents, Phytogenic
Clinical trial
Nanomedicine
chemistry
Drug delivery
business
Drug carrier
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....de7f4ec387b0af609c81bf8ff9f41760