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Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
- Source :
- Trends Parasitol
- Publication Year :
- 2021
-
Abstract
- Strategies to counteract or prevent emerging drug resistance are crucial for the design of next-generation antimalarials. In the past, resistant parasites were generally identified following treatment failures in patients, and compounds would have to be abandoned late in development. An early understanding of how candidate therapeutics lose efficacy as parasites evolve resistance is important to facilitate drug design and improve resistance detection and monitoring up to the postregistration phase. We describe a new strategy to assess resistance to antimalarial compounds as early as possible in preclinical development by leveraging tools to define the Plasmodium falciparum resistome, predict potential resistance risks of clinical failure for candidate therapeutics, and inform decisions to guide antimalarial drug development.
- Subjects :
- 0301 basic medicine
Drug
medicine.medical_specialty
media_common.quotation_subject
030231 tropical medicine
Plasmodium falciparum
Drug Resistance
Drug resistance
Risk Assessment
Article
03 medical and health sciences
Antimalarials
0302 clinical medicine
Medicine
Malaria, Falciparum
Intensive care medicine
media_common
Resistance (ecology)
biology
business.industry
Drug discovery
biology.organism_classification
medicine.disease
Resistome
030104 developmental biology
Infectious Diseases
Drug development
Parasitology
business
Malaria
Subjects
Details
- ISSN :
- 14715007
- Volume :
- 37
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Trends in parasitology
- Accession number :
- edsair.doi.dedup.....de6d77b690d006d319e6e2e87d0e9c40