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At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer
- Source :
- J Leukoc Biol
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and metastasis of cancer cells. CXCR4 signaling contributes to critical functions of stromal cells in cancer, including angiogenesis and multiple cell types in the tumor immune environment. Studies in animal models of several different types of cancers consistently demonstrate essential functions of CXCR4 in tumor initiation, local invasion, and metastasis to lymph nodes and distant organs. Data from animal models support clinical observations showing that integrated effects of CXCR4 on cancer and stromal cells correlate with metastasis and overall poor prognosis in >20 different human malignancies. Small molecules, Abs, and peptidic agents have shown anticancer efficacy in animal models, sparking ongoing efforts at clinical translation for cancer therapy. Investigators also are developing companion CXCR4-targeted imaging agents with potential to stratify patients for CXCR4-targeted therapy and monitor treatment efficacy. Here, pre-clinical studies demonstrating functions of CXCR4 in cancer are reviewed.
- Subjects :
- 0301 basic medicine
Receptors, CXCR4
Stromal cell
Angiogenesis
Immunology
Tumor initiation
Biology
Article
Metastasis
03 medical and health sciences
Chemokine receptor
0302 clinical medicine
Neoplasms
Tumor Microenvironment
medicine
Animals
Humans
Immunology and Allergy
CXCR4 antagonist
Cancer
Cell Biology
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Cancer cell
Neoplastic Stem Cells
Cancer research
Signal Transduction
Subjects
Details
- ISSN :
- 19383673 and 07415400
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Journal of Leukocyte Biology
- Accession number :
- edsair.doi.dedup.....de6d752d4d15812648945832eb8a16f9