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Malignant pleural mesothelioma in Finland: regional and gender variation
- Source :
- Acta Oncologica. 58:38-44
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Background: Malignant pleural mesothelioma (MPM) is a rare occupational cancer with a poor prognosis. Even with a multimodality treatment approach, the treatment outcomes remain unsatisfactory. The use of asbestos has been banned in most developed countries, but MPM continues to be a significant occupational disease also in these countries. Aim of this study is to identify modern epidemiology and assess equality in care.Methods: Our study cohort consists of 1010 patients diagnosed with MPM in Finland during 2000-2012. The data were collected from the Finnish Cancer Registry, the National Workers' Compensation Center Registry and the National Registry of Causes of Death, Statistics Finland.Results: Women were diagnosed a mean of 4.5 years later than males (p=.001), but survival did not differ (overall median survival 9.7 months). A workers' compensation claim was more common in males (OR 11.0 [95% CI 7.5-16.2]) and in regions with a major asbestos industry (OR 1.7 [95% CI 1.3-2.2]). One-year and three-year survivals did not differ regionally. Patients without chemotherapy treatment had an inferior survival (RR 1.8 [95% CI 1.5-2.0]). The initial survival benefit gained with pemetrexed was diluted at 51 months.Conclusions: MPM is a disease with a poor prognosis, although chemotherapy appears to improve survival time. Significant gender and regional variation exists among patients, with notable differences in diagnostic and treatment practices. Long-term outcomes with pemetrexed remain indeterminate.Impact: Emphasize centralized consult services for the diagnosis, treatment and support that patients receive for MPM, facilitating equal outcomes and compensation.
- Subjects :
- Adult
Male
Mesothelioma
Oncology
medicine.medical_specialty
Occupational cancer
Poor prognosis
Lung Neoplasms
Pleural Neoplasms
3122 Cancers
MEDLINE
030218 nuclear medicine & medical imaging
CISPLATIN
03 medical and health sciences
PROGNOSTIC-FACTORS
0302 clinical medicine
FUTURE
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Registries
Pleural Neoplasm
Sex Distribution
Finland
Aged
Aged, 80 and over
Pleural mesothelioma
business.industry
Incidence
Incidence (epidemiology)
Mesothelioma, Malignant
Gender variation
Hematology
General Medicine
Middle Aged
respiratory system
medicine.disease
respiratory tract diseases
3. Good health
030220 oncology & carcinogenesis
SURVIVAL
Female
business
Subjects
Details
- ISSN :
- 1651226X and 0284186X
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Acta Oncologica
- Accession number :
- edsair.doi.dedup.....de67cbb7a1059d13b08c403e4ecabb1a