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Double-blind trial of house-dust mite immunotherapy in asthmatic children resident at high altitude
- Source :
- Scopus-Elsevier
- Publication Year :
- 1995
- Publisher :
- Wiley, 1995.
-
Abstract
- Twenty-three Dermatophagoides pteronyssinus (Dpt)-sensitive asthmatic children aged 7-14 years entered a double-blind, placebo-controlled trial of standardized immunotherapy (IT) (Alpare) while resident at high altitude. Dpt sensitivity was evaluated by skin prick tests at different allergen concentrations at the enrollment and after 6 and 12 months of treatment. Bronchial hyperreactivity was evaluated at the same time points, and on each occasion, histamine challenge and, the following day, Dpt bronchial challenge were performed. All patients, irrespective of active treatment, improved clinically and in lung function with increased PC20 and Dpt-PD20. Alpare-treated patients had a significantly decreased sensitivity on Dpt skin testing (P < 0.009) and felt that their asthma had improved (P < 0.001) compared with placebo-treated subjects, but there was no difference between the treatment groups in lung function or bronchial challenge response. IT neither increased nor decreased bronchial histamine sensitivity. Our results indicate that Dpt IT benefits asthmatic children, but improvement by allergen avoidance at high altitude is even greater.
- Subjects :
- Male
Allergy
medicine.disease_cause
Cohort Studies
chemistry.chemical_compound
Allergen
antigen avoidance
Immunology and Allergy
Medicine
Child
Mites
medicine.diagnostic_test
biology
Altitude
Radioallergosorbent test
Respiratory disease
respiratory system
Respiratory Function Tests
Female
Immunotherapy
Bronchial Hyperreactivity
Histamine
medicine.medical_specialty
Adolescent
asthma
Immunology
immunotherapy
house-dust mite
complex mixtures
Bronchial Provocation Tests
Radioallergosorbent Test
Double-Blind Method
Internal medicine
otorhinolaryngologic diseases
Animals
Humans
Antigens, Dermatophagoides
Glycoproteins
Skin Tests
childhood
Asthma
House dust mite
business.industry
Pyroglyphidae
Allergens
medicine.disease
biology.organism_classification
respiratory tract diseases
chemistry
business
Subjects
Details
- ISSN :
- 13989995 and 01054538
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi.dedup.....de5f2fb43b84b51d79c6570a5b2476a1