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Paraneoplastic Pemphigus Associated With Castleman Tumor

Authors :
Rengui Wang
Yan Wu
Jing Wang
Suzhen Ji
Xixue Chen
Ting Li
Shuxia Yang
Xuejun Zhu
Lanbo Zhang
Ruoyu Li
Ping Tu
Aiping Wang
Haizhen Yang
Source :
Archives of Dermatology. 141
Publication Year :
2005
Publisher :
American Medical Association (AMA), 2005.

Abstract

Background Castleman tumor, a rare lymphoproliferative disorder, is one of the associated tumors in paraneoplastic pemphigus. We analyzed the characteristics of a group of patients with Castleman tumor to clearly understand and to improve the prognosis of the disease. Observations Ten cases of paraneoplastic pemphigus associated with Castleman tumor treated in the Department of Dermatology, Peking University First Hospital, Beijing, China, from May 1, 1999, to March 31, 2004, were analyzed for clinical aspects, characteristics and histologic features of the tumors, and computed tomographic findings. Literature was reviewed and data were compared with our cases. Castleman tumor was a frequently reported neoplasm in association with paraneoplastic pemphigus in China. The disease was found to be caused by an autoimmune reaction originating from the B lymphocytes in the Castleman tumor. Conclusions Castleman tumor in association with paraneoplastic pemphigus is a commonly reported subtype of paraneoplastic pemphigus in China. Early detection and removal of the Castleman tumor are crucial for the treatment of this tumor-associated autoimmune disease.

Details

ISSN :
0003987X
Volume :
141
Database :
OpenAIRE
Journal :
Archives of Dermatology
Accession number :
edsair.doi.dedup.....de5a99e9ae54f818020b100b84653a65
Full Text :
https://doi.org/10.1001/archderm.141.10.1285