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Paraneoplastic Pemphigus Associated With Castleman Tumor
- Source :
- Archives of Dermatology. 141
- Publication Year :
- 2005
- Publisher :
- American Medical Association (AMA), 2005.
-
Abstract
- Background Castleman tumor, a rare lymphoproliferative disorder, is one of the associated tumors in paraneoplastic pemphigus. We analyzed the characteristics of a group of patients with Castleman tumor to clearly understand and to improve the prognosis of the disease. Observations Ten cases of paraneoplastic pemphigus associated with Castleman tumor treated in the Department of Dermatology, Peking University First Hospital, Beijing, China, from May 1, 1999, to March 31, 2004, were analyzed for clinical aspects, characteristics and histologic features of the tumors, and computed tomographic findings. Literature was reviewed and data were compared with our cases. Castleman tumor was a frequently reported neoplasm in association with paraneoplastic pemphigus in China. The disease was found to be caused by an autoimmune reaction originating from the B lymphocytes in the Castleman tumor. Conclusions Castleman tumor in association with paraneoplastic pemphigus is a commonly reported subtype of paraneoplastic pemphigus in China. Early detection and removal of the Castleman tumor are crucial for the treatment of this tumor-associated autoimmune disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Paraneoplastic Syndromes
viruses
Respiratory Tract Diseases
Autoimmunity
Dermatology
Disease
medicine.disease_cause
immune system diseases
hemic and lymphatic diseases
Immunopathology
medicine
Humans
Neoplasm
Retrospective Studies
Skin
Autoimmune disease
B-Lymphocytes
integumentary system
business.industry
Castleman Disease
Castleman disease
Mouth Mucosa
virus diseases
General Medicine
Middle Aged
medicine.disease
Pemphigus
Paraneoplastic pemphigus
Female
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 0003987X
- Volume :
- 141
- Database :
- OpenAIRE
- Journal :
- Archives of Dermatology
- Accession number :
- edsair.doi.dedup.....de5a99e9ae54f818020b100b84653a65
- Full Text :
- https://doi.org/10.1001/archderm.141.10.1285