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Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
- Source :
- Current Diabetes Reports, 11(3), 211-217. Current Medicine Group, Current Diabetes Reports, Meijer, R I, Serné, E H, Smulders, Y M, van Hinsbergh, V W M, Yudkin, J S & Eringa, E C 2011, ' Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease ', Current Diabetes Reports, vol. 11, no. 3, pp. 211-217 . https://doi.org/10.1007/s11892-011-0186-y
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Obesity is associated with insulin resistance, hypertension, and cardiovascular disease, but the mechanisms underlying these associations are incompletely understood. Microvascular dysfunction may play an important role in the pathogenesis of both insulin resistance and hypertension in obesity. Adipose tissue-derived substances (adipokines) and especially inflammatory products of adipose tissue control insulin sensitivity and vascular function. In the past years, adipose tissue associated with the vasculature, or perivascular adipose tissue (PAT), has been shown to produce a variety of adipokines that contribute to regulation of vascular tone and local inflammation. This review describes our current understanding of the mechanisms linking perivascular adipose tissue to vascular function, inflammation, and insulin resistance. Furthermore, we will discuss mechanisms controlling the quantity and adipokines secretion by PAT.
- Subjects :
- medicine.medical_specialty
Endothelium
Endocrinology, Diabetes and Metabolism
Adipokine
Adipose tissue
Inflammation
Type 2 diabetes
Article
Pathogenesis
Insulin resistance
Adipokines
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Animals
Humans
Obesity
business.industry
medicine.disease
medicine.anatomical_structure
Endocrinology
Adipose Tissue
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Intracellular signaling
Immunology
medicine.symptom
business
Subjects
Details
- ISSN :
- 15390829 and 15344827
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Current Diabetes Reports
- Accession number :
- edsair.doi.dedup.....de58ac15e6216ee3b6ba154588dc19e3