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Induction chemotherapy-based larynx preservation program for locally advanced hypopharyngeal cancer: oncologic and functional outcomes and prognostic factors

Authors :
J.-C. Riss
Olivier Dassonville
Esma Saada
A. Leysalle
Marc Ettaiche
Emmanuel Chamorey
José Santini
Clair Vandersteen
Alexandre Bozec
Anne Sudaka
Karen Benezery
Jean-Michel Hannoun-Levi
Joël Guigay
Frederic Peyrade
Marie-Eve Chand
Gilles Poissonnet
François Demard
Source :
European Archives of Oto-Rhino-Laryngology. 273:3299-3306
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

To evaluate oncologic and functional outcomes and prognostic factors in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy (ICT)-based larynx preservation program in daily clinical practice. All patients with locally advanced (T3/4, N0-3, M0) hypopharyngeal squamous cell carcinoma, technically suitable for total pharyngo-laryngectomy, treated by docetaxel (75 mg/m(2), day 1), cisplatin (75 mg/m(2), day 1) and 5-fluorouracil (750 mg/m(2)/day, day 1-5) (TPF)-ICT (2-3 cycles) for larynx preservation at our institution between 2004 and 2013, were included in this retrospective study. Prognostic factors of oncologic (overall, cause-specific and recurrence-free survival: OS, SS and RFS) and functional (dysphagia outcome and severity scale, permanent enteral nutrition, larynx preservation) outcomes were assessed in univariate and multivariate analyses. A total of 53 patients (42 men and 11 women, mean age 58.6 ± 8.2 years) were included in this study. Grade 3-4 toxicities were experienced by 17 (32 %) patients during ICT. The rate of poor response (response

Details

ISSN :
14344726 and 09374477
Volume :
273
Database :
OpenAIRE
Journal :
European Archives of Oto-Rhino-Laryngology
Accession number :
edsair.doi.dedup.....de576133cf469611d427703a387fc9a0