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Retinoic Acid Receptor-Dependent Survival of Olfactory Sensory Neurons in Postnatal and Adult Mice
- Source :
- The Journal of Neuroscience. 26:3281-3291
- Publication Year :
- 2006
- Publisher :
- Society for Neuroscience, 2006.
-
Abstract
- To address the hypothesis that retinoids produced by synthesizing enzymes present in the primary olfactory system influence the mouse olfactory sensory map, we expressed a dominant-negative retinoic acid receptor selectively in olfactory sensory neurons. We show that neurons deficient in nuclear retinoid signaling are responsive to odors and form correct odorant receptor-specific axonal projections to target neurons in the olfactory bulb of the brain. Subsequent to the formation of the map, the neurons die prematurely by retrograde-driven caspase-3 activation, which resembles the previously described mechanism of neural death after olfactory bulb ablation. This neurodegenerative event is initiated the second postnatal week and occurs in the adult animal without a compensatory increase of progenitor cell proliferation. In addition, we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons. Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation.
- Subjects :
- Male
Olfactory system
Aging
Olfactory Nerve
Cell Survival
Receptors, Retinoic Acid
medicine.drug_class
Growth Cones
Retinoic acid
Apoptosis
Mice, Transgenic
Tretinoin
Sensory system
Biology
Olfactory Receptor Neurons
Mice
chemistry.chemical_compound
Cytochrome P-450 Enzyme System
Olfactory Mucosa
Retrograde Degeneration
medicine
Animals
Retinoid
Caspase 3
General Neuroscience
Cell Differentiation
Olfactory Pathways
Articles
Anatomy
Retinoic Acid 4-Hydroxylase
Olfactory Bulb
Cell biology
Olfactory bulb
Mice, Inbred C57BL
Smell
Retinoic acid receptor
medicine.anatomical_structure
Animals, Newborn
nervous system
chemistry
Caspases
Female
Olfactory ensheathing glia
Neuron
Signal Transduction
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....de50ea96bbdaa933a49789b94274e00c
- Full Text :
- https://doi.org/10.1523/jneurosci.4955-05.2006