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Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research
- Source :
- PLoS ONE, PLoS ONE, Vol 6, Iss 11, p e26100 (2011)
- Publication Year :
- 2011
- Publisher :
- Public Library of Science, 2011.
-
Abstract
- Cancer therapy selects for cancer cells resistant to treatment, a process that is fundamentally evolutionary. To what extent, however, is the evolutionary perspective employed in research on therapeutic resistance and relapse? We analyzed 6,228 papers on therapeutic resistance and/or relapse in cancers and found that the use of evolution terms in abstracts has remained at about 1% since the 1980s. However, detailed coding of 22 recent papers revealed a higher proportion of papers using evolutionary methods or evolutionary theory, although this number is still less than 10%. Despite the fact that relapse and therapeutic resistance is essentially an evolutionary process, it appears that this framework has not permeated research. This represents an unrealized opportunity for advances in research on therapeutic resistance.
- Subjects :
- Evolutionary Genetics
Cancer Treatment
lcsh:Medicine
Coding (therapy)
Evolutionary Selection
Drug resistance
Bioinformatics
Neoplasm genetics
0302 clinical medicine
Neoplasms
Natural Selection
Medicine
lcsh:Science
0303 health sciences
Multidisciplinary
Therapeutic resistance
3. Good health
Oncology
030220 oncology & carcinogenesis
Research Article
PubMed
Evolutionary Processes
Systematic Reviews
Clinical Research Design
Abstracting and Indexing
Cancer relapse
Cancer therapy
Evolution, Molecular
03 medical and health sciences
Genetics
Humans
Selection, Genetic
Biology
Evolutionary theory
030304 developmental biology
Evolutionary Biology
Subject Headings
Population Biology
Models, Genetic
Human evolutionary genetics
business.industry
lcsh:R
Computational Biology
Genomic Evolution
Chemotherapy and Drug Treatment
Clone Cells
Drug Resistance, Neoplasm
lcsh:Q
Neoplasm Recurrence, Local
business
Population Genetics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....de4eff6e0cd2d0a1857a5f8b8b9f5b47