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Hemolytic uremic syndrome after allogeneic or autologous hematopoietic stem cell transplantation for childhood malignancies
- Source :
- Bone Marrow Transplantation. 21:281-286
- Publication Year :
- 1998
- Publisher :
- Springer Science and Business Media LLC, 1998.
-
Abstract
- Of 193 children who underwent hematopoietic stem cell transplantation (HSCT) for various malignancies, 10 developed hemolytic uremic syndrome (HUS) 1 1/2-5 months later. All 10 had microangiopathic hemolytic anemia, thrombocytopenia and impaired renal function. Six of 10 presented with pericardial effusion, while three presented with hypertension. No child required plasma exchange, and all patients have survived without life-threatening long-term sequelae. By univariate analysis, the underlying diagnosis of neuroblastoma and a history of cisplatin (CDDP) administration were significantly associated with the development of HUS (P0.0001). By multivariate analysis using logistic regression, neuroblastoma and use of total body irradiation (TBI) as a conditioning regimen were significant contributing factors for HUS (P = 0.0001 and 0.036, respectively). Although CDDP administration could not be evaluated because of its strong correlation with the underlying diagnosis, we speculate that CDDP may enhance the nephrotoxicity of TBI, leading to a high incidence of HUS in patients with neuroblastoma.
- Subjects :
- Male
Hemolytic anemia
Adolescent
medicine.medical_treatment
Hematopoietic stem cell transplantation
Risk Factors
Neoplasms
medicine
Humans
Blood Transfusion
Child
Retrospective Studies
Transplantation
business.industry
Hematopoietic Stem Cell Transplantation
Infant
Hematology
medicine.disease
surgical procedures, operative
medicine.anatomical_structure
Child, Preschool
Hemolytic-Uremic Syndrome
Multivariate Analysis
Immunology
Female
Bone marrow
Stem cell
business
Complication
Kidney disease
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....de4cf689412ffd3852bc88115ddbfc62