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Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Rabies virus induces drastic behaviour modifications in infected hosts. The mechanisms used to achieve these changes in the host are not known. The main finding of this study is that a region in the rabies virus glycoprotein, with homologies to snake toxins, has the ability to alter behaviour in animals through inhibition of nicotinic acetylcholine receptors present in the central nervous system. This finding provides a novel aspect to virus receptor interaction and host manipulation by pathogens in general. The neurotoxin-like region of the rabies virus glycoprotein inhibited acetylcholine responses of α4β2 nicotinic receptors in vitro, as did full length ectodomain of the rabies virus glycoprotein. The same peptides significantly altered a nicotinic receptor induced behaviour in C. elegans and increased locomotor activity levels when injected into the central nervous system of mice. These results provide a mechanistic explanation for the behavioural changes in hosts infected by rabies virus.
- Subjects :
- 0301 basic medicine
Central Nervous System
Xenopus
Neurotoxins
lcsh:Medicine
Biology
Receptors, Nicotinic
medicine.disease_cause
Article
03 medical and health sciences
Mice
0302 clinical medicine
Protein Domains
Neurotransmitter receptor
medicine
Animals
Humans
Neurotransmitter metabolism
Amino Acid Sequence
Receptor
Caenorhabditis elegans
lcsh:Science
Conserved Sequence
Acetylcholine receptor
Glycoproteins
Multidisciplinary
Behavior, Animal
Sequence Homology, Amino Acid
Virus receptor
Rabies virus
lcsh:R
Virology
3. Good health
Receptors, Neurotransmitter
030104 developmental biology
Nicotinic agonist
Host-Pathogen Interactions
lcsh:Q
Peptides
030217 neurology & neurosurgery
Acetylcholine
medicine.drug
Protein Binding
Snake Venoms
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....de42b9f64bd25d8eb58152a58a822e23