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The MGEA6 Multigene Family Has an Active Locus on 14q and at Least Nine Pseudogenes on Different Chromosomes
- Source :
- Genomics. 75:43-48
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- The meningioma expressed antigen-6 (MGEA6) was originally identified as an immunogenic antigen in meningioma patients. Somatic hybrid panel mapping and fluorescence in situ hybridization revealed MGEA6-related sequences on different human chromosomes. Here we carry out database analysis to investigate the complexity of the MGEA6-related sequences and demonstrate the existence of a multigene family. We localized the active gene (spanning over 83 kb) to chromosome 14q and elucidated its exon/intron structure. We identified and characterized 9 processed pseudogenes on 9 different chromosomes including chromosomes 2, 3, 6, 7, 9, 10, 12, 13, and 18. We performed phylogenetic analysis and concluded that the MGEA6 pseudogenes may result from more than one retrotransposition event; we calculated divergence times of the pseudogenes to be between 21.5 and 28.9 million years ago.
- Subjects :
- Time Factors
Databases, Factual
Retroelements
Pseudogene
Molecular Sequence Data
Locus (genetics)
Biology
Evolution, Molecular
Gene mapping
Antigens, Neoplasm
Molecular evolution
Genetics
medicine
Humans
RNA, Messenger
Gene
In Situ Hybridization, Fluorescence
Phylogeny
Chromosomes, Human, Pair 14
medicine.diagnostic_test
Intron
Chromosome Mapping
Nucleic Acid Hybridization
Chromosome
Exons
Introns
Neoplasm Proteins
Alternative Splicing
Multigene Family
Pseudogenes
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....de34840653906af362d930306ec8394e