Reply: Change in grey matter volume cannot be assumed to be due to cognitive behavioural therapy

Sir, We thank Tom Kindlon for his letter, in which he raises several important issues. We will respond to all the issues in the same order as they appear in his letter. First, Tom Kindlon points out that cognitive behavioural therapy (CBT) is not a panacea for the chronic fatigue syndrome (CFS). It should be obvious from all previous meta-analyses that CBT does not lead to a full recovery in all CFS patients (while the exact numbers on improvement rates depend on a host of experimental factors like the exact type of therapy given, inclusion criteria of the study, as well as other factors …