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Impact of renin-angiotensin system inhibitors and beta-blockers on dental implant stability
- Source :
- International Journal of Implant Dentistry, International Journal of Implant Dentistry, Vol 7, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2020
-
Abstract
- Background Current experimental research suggests antihypertensive medication reduces the failure risk of dental implants due to enhanced bone remodeling. However, evidence from clinical studies evaluating the impact of antihypertensive medication on implant stability is lacking. Methods We retrospectively analyzed 377 implants in 196 patients (46 implants inserted in antihypertensive drug users (AH) and 331 implants in non-users (NAH)) for implant stability measured by radiofrequency analysis, and we determined the implant stability quotient (ISQ). AH subgroups were stratified by the use of beta-blockers, renin-angiotensin system (RAS) inhibitors, and both of the aforementioned. The impact of antihypertensive medication on ISQ values at implant insertion (primary stability) and implant exposure (secondary stability) was analyzed by a linear regression model with a regression coefficient and its 95% confidence interval (95% CI), adjusted for potential confounders. Results Time between implant insertion and implant exposure was 117.1 ± 56.6 days. ISQ values at insertion were 71.8 ± 8.7 for NAH and 74.1 ± 5.6 for AH, respectively. ISQ at exposure was 73.7 ± 8.1 for NAH and 75.7 ± 5.9 for AH. Regression analysis revealed that none of the AH subgroups were significantly related to ISQ at implant insertion. However, renin-angiotensin system inhibitors (RAS) were significantly associated with higher ISQ values at exposure (reg. coeff. 3.59, 95% CI 0.46–6.71 (p=0.025)). Conclusions Outcome of the present study indicates enhanced bone remodeling and osseointegration following dental implant insertion in patients taking RAS inhibitors than in non-users. Future randomized prospective studies must confirm these indicative results.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Urology
lcsh:Medicine
Ocean Engineering
Implant stability
Osseointegration
Bone remodeling
Renin-Angiotensin System
03 medical and health sciences
Beta-blockers
0302 clinical medicine
medicine
Humans
Prospective Studies
ISQ
Antihypertensive drug
Prospective cohort study
Dental implant
Antihypertensive Agents
030304 developmental biology
Retrospective Studies
Dental Implants
0303 health sciences
business.industry
Research
lcsh:R
Implant
030206 dentistry
Implant stability quotient
Confidence interval
lcsh:RK1-715
lcsh:Dentistry
business
Antihypertensive
Subjects
Details
- ISSN :
- 21984034
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of implant dentistry
- Accession number :
- edsair.doi.dedup.....de3180e53537da26332395e89d99ee3d