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Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels
- Source :
- Circulation Journal. 74:1135-1141
- Publication Year :
- 2010
- Publisher :
- Japanese Circulation Society, 2010.
-
Abstract
- WOS: 000278211900020<br />PubMed: 20453387<br />Background: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR. Methods and Results: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements >= 200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0 +/- 1.4 vs 2.6 +/- 1.1 mu mol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002). Conclusions: Serum ADMA levels might play a role in EBPR to exercise. (Circ J 2010; 74: 1135-1141)
- Subjects :
- Adult
Male
medicine.medical_specialty
Ambulatory blood pressure
Blood Pressure
Arginine
chemistry.chemical_compound
Predictive Value of Tests
Internal medicine
medicine
Humans
Endogenous nitric oxide
Treadmill
Exercise
Chromatography, High Pressure Liquid
business.industry
General Medicine
Odds ratio
Plasma levels
Blood Pressure Monitoring, Ambulatory
Middle Aged
Cardiovascular risk
Confidence interval
ADMA
Endocrinology
Blood pressure
chemistry
Cardiovascular Diseases
Case-Control Studies
Exaggerated blood pressure response to exercise
Hypertension
Exercise Test
Female
Cardiology and Cardiovascular Medicine
Asymmetric dimethylarginine
business
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....de2ceffccf82f4e801c901d516187b4c