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Mesenchymal Stem Cell-Derived Exosomes Exhibit Promising Potential for Treating SARS-CoV-2-Infected Patients
- Source :
- Cells, Cells, Vol 10, Iss 587, p 587 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The novel coronavirus severe acute respiratory syndrome-CoV-2 (SARS-CoV-2) is responsible for COVID-19 infection. The COVID-19 pandemic represents one of the worst global threats in the 21st century since World War II. This pandemic has led to a worldwide economic recession and crisis due to lockdown. Biomedical researchers, pharmaceutical companies, and premier institutes throughout the world are claiming that new clinical trials are in progress. During the severe phase of this disease, mechanical ventilators are used to assist in the management of outcomes; however, their use can lead to the development of pneumonia. In this context, mesenchymal stem cell (MSC)-derived exosomes can serve as an immunomodulation treatment for COVID-19 patients. Exosomes possess anti-inflammatory, pro-angiogenic, and immunomodulatory properties that can be explored in an effort to improve the outcomes of SARS-CoV-2-infected patients. Currently, only one ongoing clinical trial (NCT04276987) is specifically exploring the use of MSC-derived exosomes as a therapy to treat SARS-CoV-2-associated pneumonia. The purpose of this review is to provide insights of using exosomes derived from mesenchymal stem cells in management of the co-morbidities associated with SARS-CoV-2-infected persons in direction of improving their health outcome. There is limited knowledge of using exosomes in SARS-CoV-2; the clinicians and researchers should exploit exosomes as therapeutic regime.
- Subjects :
- medicine.medical_specialty
Pneumonia, Viral
Neovascularization, Physiologic
Context (language use)
Disease
Review
exosomes
medicine.disease_cause
Immunomodulation
Extracellular Vesicles
Pandemic
medicine
Humans
Intensive care medicine
lcsh:QH301-705.5
Respiratory Tract Infections
Coronavirus
anti-inflammatory
Inflammation
mesenchymal stem cells
business.industry
SARS-CoV-2
Mesenchymal stem cell
fungi
COVID-19
General Medicine
medicine.disease
Microvesicles
Clinical trial
Pneumonia
lcsh:Biology (General)
Cytokines
business
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....de25c17127406b6e7c06c788b7e8f8be