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Refined linkage disequilibrium and physical mapping of the gene locus for X-linked dystonia-parkinsonism (DYT3)
- Source :
- Genomics. 60(3)
- Publication Year :
- 1999
-
Abstract
- X-linked dystonia-parkinsonism (XDP) is a recessive disorder characterized by generalized dystonia with some patients exhibiting parkinsonism. The disease gene, DYT3, is located between DXS453 (DXS993) and DXS559, and strongest linkage disequilibrium is found distal to DXS7117 and proximal to DXS559. We have isolated and analyzed four novel polymorphic markers between DXS7117 and DXS559 and, by haplotype analysis, have narrowed the candidate interval to
- Subjects :
- Genetic Markers
Linkage disequilibrium
X Chromosome
Genetic Linkage
X-Linked Dystonia Parkinsonism
Biology
Linkage Disequilibrium
Contig Mapping
Gene mapping
Parkinsonian Disorders
Genetics
Humans
Gene
X chromosome
Expressed Sequence Tags
Contig
Haplotype
food and beverages
Chromosome Mapping
Syndrome
Cosmids
Physical Chromosome Mapping
Dystonia
Tandem Repeat Sequences
Cosmid
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 60
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....de241547923efee79adb99cb744aa1c9