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Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae
- Publication Year :
- 2013
- Publisher :
- American Society for Microbiology, 2013.
-
Abstract
- We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.
- Subjects :
- Male
Time Factors
antibiotic resistance
Klebsiella pneumoniae
cephalosporin
vancomycin
Minocycline
Tigecycline
Logistic regression
drug treatment failure
quinolone derivative
metronidazole
Drug Resistance, Multiple, Bacterial
purl.org/pe-repo/ocde/ford#3.02.21 [https]
antibiotic therapy
Pharmacology (medical)
Aged, 80 and over
clinical article
Middle Aged
Anti-Bacterial Agents
multidrug resistant Klebsiella pneumoniae
Infectious Diseases
monotherapy
Female
tigecycline
Charlson Comorbidity Index
medicine.drug
drug exposure
bacterium culture
Microbial Sensitivity Tests
linezolid
Biology
Independent predictor
Epidemiology and Surveillance
Microbiology
carbapenem
medicine
Humans
follow up
controlled study
human
Aged
Pharmacology
bacterium isolate
molecular typing
polymyxin
Odds ratio
case control study
clindamycin
biology.organism_classification
bacterial strain
Confidence interval
Klebsiella Infections
Logistic Models
Case-Control Studies
Nested case-control study
aminoglycoside
urinary tract infection
Multidrug resistant Klebsiella pneumoniae
Follow-Up Studies
aztreonam
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....de2044c50180ed325d976ee95a726f64