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Cardiovascular Effects of CAR T Cell Therapy
- Source :
- JACC. CardioOncology, Vol 2, Iss 2, Pp 193-203 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Anti-CD19 chimeric antigen receptor (CAR) T cell therapy holds great promise in the treatment of patients with hematologic malignancies. A high occurrence of cardiac dysfunction has been noted in children treated with CAR T cell therapy. Objectives The aim of this study was to define the occurrence of major adverse cardiovascular events (MACE) in adult patients treated with CAR T cell therapy and assess the relationships among clinical factors, echocardiographic parameters, laboratory values, and cardiovascular outcomes. Methods Baseline clinical, laboratory, and echocardiographic parameters were collected in 145 adult patients undergoing CAR T cell therapy. MACE included cardiovascular death, symptomatic heart failure, acute coronary syndrome, ischemic stroke, and de novo cardiac arrhythmia. Baseline parameters associated with MACE were identified using Cox proportional cause-specific hazards regression analysis. Results Thirty-one patients had MACE (41 events) at a median time of 11 days (interquartile range: 6 to 151 days) after CAR T cell infusion. The median follow-up period was 456 days (interquartile range: 128 to 1,214 days). Sixty-one patients died. Cytokine release syndrome (CRS) occurred 176 times in 104 patients; the median time to CRS was 6 days (interquartile range: 1 to 8 days). The Kaplan-Meier estimates for MACE and CRS at 30 days were 17% and 53%, respectively. The Kaplan-Meier estimates for survival at 1 year was 71%. Multivariable Cox proportional cause-specific hazards regression analysis determined that baseline creatinine and grade 3 or 4 CRS were independently associated with MACE. Conclusions Patients treated with CAR T cell therapy are at an increased risk for MACE and may benefit from cardiovascular surveillance. Further large prospective studies are needed to confirm the incidence and risk factors predictive of MACE.
- Subjects :
- CAR T cells
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Acute coronary syndrome
cardio-oncology
business.industry
cardiovascular
Incidence (epidemiology)
Retrospective cohort study
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
lcsh:RC254-282
Cytokine release syndrome
Oncology
lcsh:RC666-701
Interquartile range
Internal medicine
Heart failure
medicine
cardiovascular diseases
Cardiology and Cardiovascular Medicine
Prospective cohort study
business
Mace
Subjects
Details
- ISSN :
- 26660873
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- JACC: CardioOncology
- Accession number :
- edsair.doi.dedup.....de1257c82a69a1ab9ad7e89025b2418c