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Regenerating functional heart tissue for myocardial repair
- Source :
- Cellular and Molecular Life Sciences. 69:2635-2656
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside.
- Subjects :
- Heart Injury
medicine.medical_specialty
Heart disease
medicine.medical_treatment
Biology
Regenerative medicine
Article
Cellular and Molecular Neuroscience
Internal medicine
Cellular cardiomyoplasty
medicine
Animals
Humans
Regeneration
Myocardial infarction
Molecular Biology
Pharmacology
Heart transplantation
Tissue Engineering
Myocardium
Heart
Cell Biology
medicine.disease
Cardiovascular physiology
Heart Injuries
Heart failure
Cardiology
Molecular Medicine
Subjects
Details
- ISSN :
- 14209071 and 1420682X
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....de0ffd026ae07209f6c2eb2790f0728e