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Malignant perineurioma (malignant peripheral nerve sheath tumor with perineural differentiation)
- Source :
- Clinical Neuropathology. 31:424-429
- Publication Year :
- 2012
- Publisher :
- Dustri-Verlgag Dr. Karl Feistle, 2012.
-
Abstract
- The great majority of malignant peripheral nerve sheath tumors (MPNST) exhibit Schwannian differentiation. In recent years, a subset of perineurial MPNST (malignant perineurioma) has been identified based on their histologic, immunohistochemical and ultrastructural features. Immunopositivity for epithelial membrane antigen (EMA), glut-1 and claudin-1, is characteristic. Such tumors must be distinguished from benign perineurioma and a variety of atypical or malignant soft tissue tumors featuring EMA positivity. Herein, we report a perineurial MPNST involving the buttock of a 42-year-old woman. Nerve involvement was noted. The clinicopathologic features of reported examples are ummarized and key differential diagnoses are discussed.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Soft Tissue Neoplasms
Malignant peripheral nerve sheath tumor
Nerve Sheath Neoplasms
Pathology and Forensic Medicine
Perineurioma
Neoplasm Recurrence
Peripheral Nerve Sheath Tumors
medicine
Humans
Malignant soft tissue tumors
business.industry
Malignant Perineurioma
General Medicine
medicine.disease
Immunohistochemistry
Neurology
Buttocks
Female
Neurology (clinical)
Neoplasm Recurrence, Local
Epithelial Membrane Antigen
business
Subjects
Details
- ISSN :
- 07225091
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Clinical Neuropathology
- Accession number :
- edsair.doi.dedup.....de0a1ec8363761d5678c5bb7850b1b5a