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Toluene-induced hearing loss in phenobarbital treated rats
- Source :
- Neurotoxicology and teratology. 30(1)
- Publication Year :
- 2007
-
Abstract
- Exposure to aromatic organic solvents may induce hearing loss in rats, the cochlea being the primary target. The aim of this study which was carried out in rat, was to evaluate the impact of the hepatic metabolism of toluene on its ototoxic potency. To this end, the solvent hepatic metabolism was shifted by treating the rats with 50 mg/kg/d of phenobarbital (PhB), a potent inducer of the microsomal cytochromes P450 system, alcohol and aldehyde dehydrogenases, and glutathione-S-transferases. The two main urinary metabolites of the oxidative and conjugate pathways [hippuric (HA) and benzyl mercapturic acids (BMA) respectively] confirmed the efficacy of the PhB treatment. For the PhB-induced rats, the amount of excreted HA increased by 43% and the amount of BMA by 35%. Auditory function impairments were assessed using auditory-evoked potentials. On completion of the auditory tests, the organs of Corti were dissected to evaluate hair cell losses. The permanent auditory threshold shifts were approximately 15 dB greater in the toluene-exposed rats than in the PhB-induced rats. Both the functional and morphological data confirmed that PhB treatment can decrease the ototoxic potency of toluene.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Otoacoustic Emissions, Spontaneous
Aldehyde dehydrogenase
Toxicology
Cellular and Molecular Neuroscience
Developmental Neuroscience
Ototoxicity
Audiometry
Internal medicine
Prohibitins
medicine
Potency
Animals
Drug Interactions
Rats, Long-Evans
Hearing Loss
Cochlea
Toluene toxicity
Analysis of Variance
biology
Chemistry
Hippurates
Auditory Threshold
Metabolism
medicine.disease
Acetylcysteine
Rats
Disease Models, Animal
Endocrinology
Biochemistry
Phenobarbital
biology.protein
Excitatory Amino Acid Antagonists
Drug metabolism
medicine.drug
Toluene
Subjects
Details
- ISSN :
- 08920362
- Volume :
- 30
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurotoxicology and teratology
- Accession number :
- edsair.doi.dedup.....ddf958c659ea765ee59b18fcd12c2996