Prednisolone biotransformation by the green alga T76 Scenedesmus quadricauda

Authors :: Antonino Pollio
Lucio Previtera
Antonio Fiorentino
Marina DellaGreca
Gabriele Pinto
DELLA GRECA, Marina
Previtera, L
Fiorentino, A
Pinto, Gabriele
Pollio, Antonino
Fiorentino, A.
Pollio, A.
Previtera, Lucio
Dellagreca, M
Fiorentino, Antonio
Pinto, G
Publication Year :: 1997
Publisher :: Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010, 1997.
Abstract: Exogenus prednisolone is biotransformed in cultures of the green alga T76 Scenedesmus quadricauda in two main bioproducts, which have been purified by chromatographic processes and identified by spectroscopic means. The first compound is the 5α-hydroxyderivative of prednisolone and might be formed by a simple hydration of the Δ 4 double bond. The latter rises from a complex rearrangement. It is rather unstable and undergoes oxidation by atmospheric oxygen to a hydroperoxide which slowly decays to the corresponding hydroxyderivative.