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Novel cardiac cell subpopulations: Pnmt-derived cardiomyocytes
- Source :
- Open Biology, Vol 10, Iss 8 (2020), Open Biology
- Publication Year :
- 2020
- Publisher :
- The Royal Society, 2020.
-
Abstract
- Diversity among highly specialized cells underlies the fundamental biology of complex multi-cellular organisms. One of the essential scientific questions in cardiac biology has been to define subpopulations within the heart. The heart parenchyma comprises specialized cardiomyocytes (CMs). CMs have been canonically classified into a few phenotypically diverse subpopulations largely based on their function and anatomic localization. However, there is growing evidence that CM subpopulations are in fact numerous, with a diversity of genetic origin and putatively different roles in physiology and pathophysiology. In this chapter, we introduce a recently discovered CM subpopulation: phenylethanolamine- N -methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs). We discuss: (i) canonical classifications of CM subpopulations; (ii) discovery of PdCMs; (iii) Pnmt and the role of catecholamines in the heart; similarities and dissimilarities of PdCMs and canonical CMs; and (iv) putative functions of PdCMs in both physiological and pathological states and future directions, such as in intra-cardiac adrenergic signalling.
- Subjects :
- phenylethanolamine n-methyl transferase
Organogenesis
Cellular differentiation
Cell Plasticity
Immunology
Adrenergic
Review
Review Article
030204 cardiovascular system & hematology
Biology
General Biochemistry, Genetics and Molecular Biology
Cardiac cell
cardiac cellular subpopulations
03 medical and health sciences
Catecholamines
0302 clinical medicine
Parenchyma
Animals
Humans
Transferase
Myocytes, Cardiac
lcsh:QH301-705.5
030304 developmental biology
0303 health sciences
Myocardium
Phenylethanolamine N-Methyltransferase
General Neuroscience
Age Factors
pnmt
pdcms
Pathophysiology
Electrophysiological Phenomena
cardiac adrenergic signalling
Phenotype
lcsh:Biology (General)
pnmt-derived cardiomyocytes
Neuroscience
Biomarkers
Function (biology)
Subjects
Details
- Language :
- English
- ISSN :
- 20462441
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Open Biology
- Accession number :
- edsair.doi.dedup.....ddf427c713c90d05bc6a459fa5bb7183