CAGE Displays Oncogenic Potential and Induces Cytolytic T Lymphocyte Activity

The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.